Top Smoke or Cannabis-Related Businesses in South Dakota 2026 Medical Only

Short answer: South Dakota has 97 smoke or cannabis-related businesses listed in our 2026 directory, including 51 dispensaries, 23 smoke shops, 6 CBD stores. Filter by category, browse by city, or see compliance regulations below.

97

Smoke or cannabis-related businesses

51

Dispensaries

4.7★

Average rating

View South Dakota cannabis regulations →

Cities in South Dakota

Sioux Falls 28 listings Rapid City 23 listings Watertown 10 listings Brookings 7 listings Aberdeen 7 listings Yankton 3 listings North Sioux City 3 listings Winner 1 listing Wanblee 1 listing Tea 1 listing Sturgis 1 listing Platte 1 listing Pine Ridge 1 listing Mitchell 1 listing Lead 1 listing Huron 1 listing Hot Springs 1 listing Harrisburg 1 listing Fort Thompson 1 listing Fort Pierre 1 listing Deadwood 1 listing Colome 1 listing Belle Fourche 1 listing

Businesses in South Dakota

Four Winds Farm Apothecary — CBD Store in Sioux Falls, SD

Four Winds Farm Apothecary

Sioux Falls, South Dakota

★★★★★5.0(Google)

Flower Shop Dispensary - Brookings — Dispensaries in Brookings, SD

Flower Shop Dispensary - Brookings

Brookings, South Dakota

★★★★★5.0(Google)

Dispensary of Watertown — Dispensaries in Watertown, SD

Dispensary of Watertown

Watertown, South Dakota

★★★★★5.0(Google)

Sioux Falls Loud Vape & Tobacco — Smoke Shop in Sioux Falls, SD

Sioux Falls Loud Vape & Tobacco

Sioux Falls, South Dakota

★★★★★5.0(Google)

Tobacco and vape — Smoke Shop in Watertown, SD

Tobacco and vape

Watertown, South Dakota

★★★★★5.0(Google)

America's Smoke - Watertown — Smoke Shop in Watertown, SD

America's Smoke - Watertown

Watertown, South Dakota

★★★★★5.0(Google)

Northern Hills Alternative Health — Ancillary Services in Rapid City, SD

Northern Hills Alternative Health

Ancillary Services

Rapid City, South Dakota

★★★★★5.0(Google)

The CBD Centers of Sioux Falls — CBD Store in Sioux Falls, SD

The CBD Centers of Sioux Falls

Sioux Falls, South Dakota

★★★★★5.0(Google)

Your CBD Store - Sioux Falls East, SD — CBD Store in Sioux Falls, SD

Your CBD Store - Sioux Falls East, SD

Sioux Falls, South Dakota

★★★★★5.0(Google)

Black Hills CBD Jackson — CBD Store in Rapid City, SD

Black Hills CBD Jackson

Rapid City, South Dakota

★★★★★5.0(Google)

Your CBD Store | SUNMED - Sioux Falls, SD — Hemp Business in Sioux Falls, SD

Your CBD Store | SUNMED - Sioux Falls, SD

Sioux Falls, South Dakota

★★★★★5.0(Google)

Bad River Cannabis — Cultivator in Sioux Falls, SD

Bad River Cannabis

Sioux Falls, South Dakota

★★★★★5.0(Google)

Warpath Cannabis — Consumption Lounge in Rapid City, SD

Warpath Cannabis

Consumption Lounge

Rapid City, South Dakota

★★★★★5.0(Google)

Happy Flower Healing — Hemp Business in Watertown, SD

Happy Flower Healing

Watertown, South Dakota

★★★★★5.0(Google)

High Plainz Dispensary — Dispensaries in Fort Thompson, SD

High Plainz Dispensary

Fort Thompson, South Dakota

★★★★★5.0(Google)

Yellowstone Cannabis Care - A Dakota Green Cultivators Dispensary — Dispensaries in Fort Pierre, SD

Yellowstone Cannabis Care - A Dakota Green Cultivators Dispensary

Fort Pierre, South Dakota

★★★★★5.0(Google)

Organic Trading — Dispensaries in Winner, SD

Organic Trading

Winner, South Dakota

★★★★★5.0(Google)

Superior Buds Medical Dispensary — Dispensaries in Mitchell, SD

Superior Buds Medical Dispensary

Mitchell, South Dakota

★★★★★5.0(Google)

Cannabis Connection — Dispensaries in Brookings, SD

Cannabis Connection

Brookings, South Dakota

★★★★★5.0(Google)

The Dispensary — Dispensaries in Harrisburg, SD

The Dispensary

Harrisburg, South Dakota

★★★★★5.0

Trail's Head Cannabis Co. — Dispensaries in Deadwood, SD

Trail's Head Cannabis Co.

Deadwood, South Dakota

★★★★★5.0(Google)

East River Farms Medical Dispensary — Dispensaries in Sioux Falls, SD

East River Farms Medical Dispensary

Sioux Falls, South Dakota

★★★★★5.0(Google)

Dakota Herb LLC — Dispensaries in Huron, SD

Dakota Herb LLC

Huron, South Dakota

★★★★★5.0(Google)

Dakota Health and Wellness — Dispensaries in North Sioux City, SD

Dakota Health and Wellness

North Sioux City, South Dakota

★★★★★5.0(Google)

Roy'zzz Premium Cannabis — Dispensaries in Yankton, SD

Roy'zzz Premium Cannabis

Yankton, South Dakota

★★★★★5.0(Google)

Roy'zzz of Sioux Falls — Dispensaries in Sioux Falls, SD

Roy'zzz of Sioux Falls

Sioux Falls, South Dakota

★★★★★5.0

Roy'zzz Premium Cannabis — Dispensaries in Sioux Falls, SD

Roy'zzz Premium Cannabis

Sioux Falls, South Dakota

★★★★★4.9(Google)

East River Farms Medical Dispensary — Dispensaries in Sioux Falls, SD

East River Farms Medical Dispensary

Sioux Falls, South Dakota

★★★★★4.9(Google)

Genesis Farms Cannabis Dispensary — Dispensaries in Sioux Falls, SD

Genesis Farms Cannabis Dispensary

Sioux Falls, South Dakota

★★★★★4.9(Google)

Genesis Farms Cannabis Dispensary — Dispensaries in Aberdeen, SD

Genesis Farms Cannabis Dispensary

Aberdeen, South Dakota

★★★★★4.9(Google)

Roy'zzz Premium Cannabis — Dispensaries in Watertown, SD

Roy'zzz Premium Cannabis

Watertown, South Dakota

★★★★★4.9(Google)

VIP Smoke Shop — Smoke Shop in Sioux Falls, SD

VIP Smoke Shop

Sioux Falls, South Dakota

★★★★★4.9(Google)

Puff city smoke shop — Smoke Shop in Sioux Falls, SD

Puff city smoke shop

Sioux Falls, South Dakota

★★★★★4.9(Google)

Cloud 9 — Smoke Shop in Rapid City, SD

Cloud 9

Rapid City, South Dakota

★★★★★4.9(Google)

One stop tobacco vape & more - Drive through — Smoke Shop in Aberdeen, SD

One stop tobacco vape & more - Drive through

Aberdeen, South Dakota

★★★★★4.9(Google)

Pure Bliss Dispensary — Dispensaries in Sioux Falls, SD

Pure Bliss Dispensary

Sioux Falls, South Dakota

★★★★★4.9(Google)

Herb N Legend — Hemp Business in Sioux Falls, SD

Herb N Legend

Sioux Falls, South Dakota

★★★★★4.9(Google)

Five Leaf Clover Smoke Shop — Smoke Shop in Colome, SD

Five Leaf Clover Smoke Shop

Colome, South Dakota

★★★★★4.9(Google)

Puffy's Dispensary — Dispensaries in Rapid City, SD

Puffy's Dispensary

Rapid City, South Dakota

★★★★★4.9(Google)

The Tea Tree — Dispensaries in Tea, SD

The Tea Tree

Tea, South Dakota

★★★★★4.9(Google)

Genesis Farms Cannabis Dispensary — Dispensaries in Rapid City, SD

Genesis Farms Cannabis Dispensary

Rapid City, South Dakota

★★★★★4.9(Google)

KindCare of South Dakota Dispensary — Dispensaries in North Sioux City, SD

KindCare of South Dakota Dispensary

North Sioux City, South Dakota

★★★★★4.9(Google)

All The Smoke & Vape Shop — Smoke Shop in Aberdeen, SD

All The Smoke & Vape Shop

Aberdeen, South Dakota

★★★★★4.8(Google)

The Black Hills Weed Shop — Dispensaries in Rapid City, SD

The Black Hills Weed Shop

Rapid City, South Dakota

★★★★★4.8(Google)

Genesis Farms Cannabis Dispensary — Dispensaries in Rapid City, SD

Genesis Farms Cannabis Dispensary

Rapid City, South Dakota

★★★★★4.8(Google)

Flower Shop Dispensary - Aberdeen — Dispensaries in Aberdeen, SD

Flower Shop Dispensary - Aberdeen

Aberdeen, South Dakota

★★★★★4.8(Google)

Dakota Herb LLC — Dispensaries in Aberdeen, SD

Dakota Herb LLC

Aberdeen, South Dakota

★★★★★4.8(Google)

Genesis Farms Cannabis Dispensary — Dispensaries in Brookings, SD

Genesis Farms Cannabis Dispensary

Brookings, South Dakota

★★★★★4.8(Google)

Smokes 4 Less Rapids — Smoke Shop in Rapid City, SD

Smokes 4 Less Rapids

Rapid City, South Dakota

★★★★★4.8(Google)

Roll N Smoke — Smoke Shop in Brookings, SD

Roll N Smoke

Brookings, South Dakota

★★★★★4.8(Google)

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Cannabis in South Dakota

South Dakota has a medical cannabis program that was approved by voters in 2020, allowing patients with qualifying conditions to purchase from licensed dispensaries. The South Dakota Department of Health oversees the program, and dispensaries have opened in Sioux Falls, Rapid City, and other communities. A recreational legalization measure was also approved by voters in 2020 but was struck down by the state Supreme Court on a technicality. Recreational cannabis remains illegal in South Dakota, though advocacy for adult-use reform continues.

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Frequently Asked Questions — Cannabis in South Dakota

Is cannabis legal in South Dakota?

South Dakota has a medical-only cannabis program. Recreational legalization was voter-approved in 2020 but struck down by the state Supreme Court.

How old do you have to be to buy cannabis in South Dakota?

You must be at least 18 years old and hold a valid South Dakota medical cannabis card to purchase from a licensed dispensary.

Where can I buy cannabis in South Dakota?

Medical cannabis dispensaries operate in Sioux Falls, Rapid City, Aberdeen, Brookings, and other communities across the state.

Is cannabis delivery available in South Dakota?

Cannabis delivery is not widely available in South Dakota. Most patients purchase in person at licensed dispensary locations.

Listings & accuracy: Business listings are aggregated from public sources and user submissions and may be inaccurate, incomplete, or out of date. Inclusion is not an endorsement, and Cannabis Promotions does not independently verify the licensing or legal status of listed businesses — always confirm directly with the business and the relevant state or provincial regulator. Reviews reflect the views of their authors, not Cannabis Promotions.

Not professional advice: Content is provided for general informational purposes only and does not constitute legal, financial, tax, or other professional advice.

Age & products: You must be 21 or older to use this site. Cannabis Promotions provides custom branding, merchandise, and packaging products only — we do not sell, distribute, or facilitate the sale of cannabis, THC, or any controlled substance.